Assay Detail
Functional
CHEMBL810198
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In vitro cytotoxicity against mouse TLX5 lymphoma cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | TLX-5 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Antitumor imidazotetrazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozolomide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.00 | 5.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417671 | — | — | 1 | 5.90 |
| CHEMBL435951 | MITOZOLOMIDE | 2.0 | 1 | 5.60 |
| CHEMBL810 | TEMOZOLOMIDE | 4.0 | 1 | 5.30 |
| CHEMBL37046 | — | — | 1 | 4.89 |
| CHEMBL31897 | — | — | 1 | 4.80 |
| CHEMBL284302 | — | — | 1 | 4.60 |
| CHEMBL37801 | — | — | 1 | 4.46 |
| CHEMBL36976 | — | — | 1 | 4.43 |
| CHEMBL416597 | — | — | 1 | - |
| CHEMBL37881 | — | — | 1 | - |
| CHEMBL36489 | — | — | 1 | - |
| CHEMBL36209 | — | — | 1 | - |
| CHEMBL36730 | — | — | 1 | - |
| CHEMBL284712 | — | — | 1 | - |
| CHEMBL288517 | — | — | 1 | - |
| CHEMBL37240 | — | — | 1 | - |
| CHEMBL36935 | — | — | 1 | - |
| CHEMBL37125 | — | — | 1 | - |
| CHEMBL290356 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417671 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL435951 | MITOZOLOMIDE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL810 | TEMOZOLOMIDE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL37046 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL31897 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL284302 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL37801 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL36976 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL416597 | — | IC50 | = | 325000.0 | nM | - |
| CHEMBL37881 | — | IC50 | = | 375000.0 | nM | - |
| CHEMBL36489 | — | IC50 | = | 108000.0 | nM | - |
| CHEMBL36209 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL36730 | — | IC50 | = | 380000.0 | nM | - |
| CHEMBL284712 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL288517 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL37240 | — | IC50 | = | 400000.0 | nM | - |
| CHEMBL36935 | — | IC50 | = | 225000.0 | nM | - |
| CHEMBL37125 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL290356 | — | IC50 | = | 350000.0 | nM | - |