Assay Detail
Binding
CHEMBL810263
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its ability to inhibit human embryonal kidney cell derived steroid sulfatase activity in transforming [3H]E1S (estrone sulfate) to E1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | kidney |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Potent inhibition of steroid sulfatase activity by 3-O-sulfamate 17alpha-benzyl(or 4'-tert-butylbenzyl)estra-1,3,5(10)-trienes: combination of two substituents at positions C3 and c17alpha of estradiol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.53 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1627465 | — | — | 1 | 9.82 |
| CHEMBL1627878 | — | — | 1 | 9.41 |
| CHEMBL122708 | EMATE | — | 1 | 8.68 |
| CHEMBL518966 | — | — | 1 | 8.08 |
| CHEMBL482212 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1627465 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL1627878 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL122708 | EMATE | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL518966 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL482212 | — | IC50 | = | 230.0 | nM | 6.64 |