Assay Detail
Functional
CHEMBL810776
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Inhibitory concentration against T cell proliferation using concanavalin A stimulated mice spleen cells
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Spleen |
| Cell Type | T-cell |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-activity relationships of quinazoline derivatives: dual-acting compounds with inhibitory activities toward both TNF-alpha production and T cell proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.87 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 8.30 |
| CHEMBL357569 | — | — | 1 | 6.70 |
| CHEMBL153483 | — | — | 1 | 6.30 |
| CHEMBL434503 | — | — | 1 | 6.10 |
| CHEMBL153791 | — | — | 1 | 6.05 |
| CHEMBL153147 | — | — | 1 | 5.96 |
| CHEMBL358920 | — | — | 1 | 5.92 |
| CHEMBL345503 | — | — | 1 | 5.92 |
| CHEMBL356646 | — | — | 1 | 5.85 |
| CHEMBL149553 | — | — | 1 | 5.85 |
| CHEMBL152971 | — | — | 1 | 5.58 |
| CHEMBL149693 | — | — | 1 | 5.50 |
| CHEMBL153233 | — | — | 1 | 5.47 |
| CHEMBL149807 | — | — | 1 | 5.37 |
| CHEMBL153733 | — | — | 1 | 5.32 |
| CHEMBL150520 | — | — | 1 | 5.25 |
| CHEMBL152938 | — | — | 1 | 5.08 |
| CHEMBL153146 | — | — | 1 | 5.07 |
| CHEMBL153144 | — | — | 1 | - |
| CHEMBL153314 | — | — | 1 | - |
| CHEMBL155045 | — | — | 1 | - |
| CHEMBL153357 | — | — | 1 | - |
| CHEMBL421 | SULFASALAZINE | 4.0 | 1 | - |
| CHEMBL153703 | — | — | 1 | - |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | - |
| CHEMBL153008 | — | — | 1 | - |
| CHEMBL153563 | — | — | 1 | - |
| CHEMBL152929 | — | — | 1 | - |
| CHEMBL153167 | — | — | 1 | - |
| CHEMBL153603 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL357569 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL153483 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL434503 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL153791 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL153147 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL358920 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL345503 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL356646 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL149553 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL152971 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL149693 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL153233 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL149807 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL153733 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL150520 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL152938 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL153146 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL153144 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL153314 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL155045 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL153357 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL421 | SULFASALAZINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL153703 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL63 | ROLIPRAM | IC50 | > | 10000.0 | nM | - |
| CHEMBL153008 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL153563 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL152929 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL153167 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL153603 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL149800 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL424337 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL265800 | — | IC50 | > | 10000.0 | nM | - |