Assay Detail
Functional
CHEMBL810778
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of proliferation of PMA and ionomycin stimulated murine T cells.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | T-cell |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Preparation and in vitro activities of naphthyl and indolyl ether derivatives of the FK-506 related immunosuppressive macrolide ascomycin
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.94 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431360 | — | — | 1 | 9.70 |
| CHEMBL68027 | — | — | 1 | 9.70 |
| CHEMBL419817 | — | — | 1 | 9.70 |
| CHEMBL70822 | — | — | 1 | 9.15 |
| CHEMBL302040 | — | — | 1 | 8.74 |
| CHEMBL71849 | — | — | 1 | 8.27 |
| CHEMBL303180 | — | — | 1 | 8.26 |
| CHEMBL430809 | — | — | 1 | 7.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431360 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL68027 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL419817 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL70822 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL302040 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL71849 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL303180 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL430809 | — | IC50 | = | 10.2 | nM | 7.99 |