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Assay Detail

CHEMBL810908

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Functional
Agonistic activity as progesterone receptor induced alkaline phosphatase activity in T47D human breast cancer cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type T47D
Confidence 9 — Direct single protein target
Curated By Expert

Target

Progesterone receptor (CHEMBL208)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel pyrrole-containing progesterone receptor modulators.
Collins MA, Hudak V, Bender R, Fensome A, Zhang P, Miller L, Winneker RC, Zhang Z, Zhu Y, Cohen J, Unwalla RJ, Wrobel J.
Bioorg Med Chem Lett (2004) 14 : 2185 -2189
PubMed 15081005 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 2 8.85 8.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL67860 1 8.96
CHEMBL431380 1 8.74

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL67860 EC50 = 1.1 nM 8.96
CHEMBL431380 EC50 = 1.8 nM 8.74