Assay Detail
Functional
CHEMBL811062
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Concentration required to inhibit thrombin hydrolysis of the chromogenic substrate
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Active site-directed synthetic thrombin inhibitors: synthesis, in vitro and in vivo activity profile of BMY 44621 and analogs. An examination of the role of the amino group in the D-Phe-Pro-Arg-H series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.15 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319396 | — | — | 1 | 7.31 |
| CHEMBL317878 | — | — | 1 | 6.82 |
| CHEMBL319227 | — | — | 1 | 6.41 |
| CHEMBL443480 | — | — | 1 | 6.23 |
| CHEMBL317414 | — | — | 1 | 6.23 |
| CHEMBL103848 | — | — | 1 | 6.08 |
| CHEMBL317224 | — | — | 1 | 6.06 |
| CHEMBL419168 | — | — | 1 | 5.93 |
| CHEMBL102849 | — | — | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319396 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL317878 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL319227 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL443480 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL317414 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL103848 | — | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL317224 | — | EC50 | = | 880.0 | nM | 6.06 |
| CHEMBL419168 | — | EC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL102849 | — | EC50 | = | 56000.0 | nM | 4.25 |