Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL811211

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against V-79 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cricetulus griseus
Cell Type V79
Confidence 1 — Organism
Curated By Expert

Target

V79 (CHEMBL614074)
Type CELL-LINE
Organism Cricetulus griseus

Publication

Identification and structure-activity relationship studies of osthol, a cytotoxic principle from Cnidium monnieri
Hitotsuyanagi Y, Kojima H, Ikuta H, Takeya K, Itokawa H
Bioorg Med Chem Lett (1996) 6 : 1791 -1794
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.51 5.25

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL299361 1 5.25
CHEMBL54243 1 5.24
CHEMBL300682 1 4.80
CHEMBL53500 1 4.77
CHEMBL50201 1 4.40
CHEMBL51628 UMBELLIFERONE 1 4.24
CHEMBL53581 1 4.24
CHEMBL51398 1 4.24
CHEMBL52229 OSTHOLE 1 4.24
CHEMBL51994 1 4.22
CHEMBL51633 1 4.22
CHEMBL51344 1 4.22
CHEMBL433093 1 -
CHEMBL300192 1 -
CHEMBL49732 HERNIARIN 1 -
CHEMBL297519 1 -
CHEMBL52267 1 -
CHEMBL6466 COUMARIN 4.0 1 -
CHEMBL299099 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL299361 IC50 = 5600.0 nM 5.25
CHEMBL54243 IC50 = 5800.0 nM 5.24
CHEMBL300682 IC50 = 16000.0 nM 4.80
CHEMBL53500 IC50 = 17000.0 nM 4.77
CHEMBL50201 IC50 = 40000.0 nM 4.40
CHEMBL51628 UMBELLIFERONE IC50 = 58000.0 nM 4.24
CHEMBL53581 IC50 = 58000.0 nM 4.24
CHEMBL51398 IC50 = 58000.0 nM 4.24
CHEMBL52229 OSTHOLE IC50 = 57000.0 nM 4.24
CHEMBL51994 IC50 = 60000.0 nM 4.22
CHEMBL51633 IC50 = 60000.0 nM 4.22
CHEMBL51344 IC50 = 60000.0 nM 4.22
CHEMBL433093 IC50 > 100000.0 nM -
CHEMBL300192 IC50 > 100000.0 nM -
CHEMBL49732 HERNIARIN IC50 > 100000.0 nM -
CHEMBL297519 IC50 > 100000.0 nM -
CHEMBL52267 IC50 > 100000.0 nM -
CHEMBL6466 COUMARIN IC50 > 100000.0 nM -
CHEMBL299099 IC50 > 100000.0 nM -