Assay Detail
Binding
CHEMBL811228
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Ability to inhibit the Steroid 17-alpha-hydroxylase/17,20 lyase enzyme by 50%.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL3522) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.62 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310662 | — | — | 1 | 8.59 |
| CHEMBL432751 | — | — | 1 | 8.55 |
| CHEMBL254328 | ABIRATERONE | 3.0 | 1 | 8.40 |
| CHEMBL79829 | — | — | 1 | 8.37 |
| CHEMBL84230 | — | — | 1 | 8.33 |
| CHEMBL310315 | — | — | 1 | 7.90 |
| CHEMBL311444 | — | — | 1 | 7.89 |
| CHEMBL271227 | ABIRATERONE ACETATE | 4.0 | 1 | 7.75 |
| CHEMBL82926 | — | — | 1 | 7.33 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 7.19 |
| CHEMBL310690 | — | — | 1 | 6.80 |
| CHEMBL2112301 | — | — | 1 | 6.57 |
| CHEMBL2112299 | — | — | 1 | 5.40 |
| CHEMBL79319 | — | — | 1 | - |
| CHEMBL439582 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310662 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL432751 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL254328 | ABIRATERONE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL79829 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL84230 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL310315 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL311444 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL271227 | ABIRATERONE ACETATE | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL82926 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL310690 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2112301 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL2112299 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL79319 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL439582 | — | IC50 | > | 10000.0 | nM | - |