Assay Detail
Binding
CHEMBL811230
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human testicular microsome Steroid 17-alpha-hydroxylase/17,20 lyase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL3522) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.77 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL78322 | — | — | 1 | 7.38 |
| CHEMBL307160 | — | — | 1 | 6.89 |
| CHEMBL442373 | — | — | 1 | 6.66 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL78322 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL307160 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL442373 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 740.0 | nM | 6.13 |