Assay Detail
Binding
CHEMBL811276
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Binding affinity towards human Tachykinin receptor 3 stably expressed in CHO cells using [125I][MePhe7]-NKB as radioligand
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The development of a novel series of non-peptide tachykinin NK3 receptor selective antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.47 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45340 | — | — | 1 | 8.14 |
| CHEMBL437797 | NEUROKININ B | — | 1 | 8.00 |
| CHEMBL47146 | — | — | 1 | 7.80 |
| CHEMBL106124 | SENKTIDE | — | 1 | 7.68 |
| CHEMBL444832 | — | — | 1 | 7.40 |
| CHEMBL44965 | — | — | 1 | 7.37 |
| CHEMBL47641 | — | — | 1 | 7.28 |
| CHEMBL44686 | — | — | 1 | 7.13 |
| CHEMBL296983 | — | — | 1 | 6.46 |
| CHEMBL45278 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45340 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL437797 | NEUROKININ B | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL47146 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL106124 | SENKTIDE | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL444832 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL44965 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL47641 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL44686 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL296983 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL45278 | — | IC50 | > | 10000.0 | nM | - |