Assay Detail
Binding
CHEMBL811284
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Inhibitory activity against cloned human Tachykinin receptor 3 in CHO cells labeled with [125I][MePhe7]-NKB
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Use of a dipeptide chemical library in the development of non-peptide tachykinin NK3 receptor selective antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.83 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45340 | — | — | 1 | 8.15 |
| CHEMBL437797 | NEUROKININ B | — | 1 | 8.01 |
| CHEMBL47146 | — | — | 1 | 7.80 |
| CHEMBL444832 | — | — | 1 | 7.80 |
| CHEMBL296014 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45340 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL437797 | NEUROKININ B | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL47146 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL444832 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL296014 | — | IC50 | = | 40.0 | nM | 7.40 |