Assay Detail
Binding
CHEMBL811287
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Inhibition of HSV-2 thymidine kinase, 2 uM [3H]thymidine and ATP as phosphate donor
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human alphaherpesvirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.65 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405761 | — | — | 1 | 7.00 |
| CHEMBL152338 | — | — | 1 | 6.75 |
| CHEMBL153866 | — | — | 1 | 6.33 |
| CHEMBL152256 | — | — | 1 | 6.00 |
| CHEMBL347128 | — | — | 1 | 5.92 |
| CHEMBL152475 | — | — | 1 | 5.80 |
| CHEMBL287727 | — | — | 1 | 5.80 |
| CHEMBL3143447 | — | — | 1 | 5.70 |
| CHEMBL406254 | — | — | 1 | 5.67 |
| CHEMBL3143935 | — | — | 1 | 5.60 |
| CHEMBL154209 | — | — | 1 | 5.57 |
| CHEMBL262742 | — | — | 1 | 5.46 |
| CHEMBL152257 | — | — | 1 | 5.41 |
| CHEMBL152838 | — | — | 1 | 5.20 |
| CHEMBL152575 | — | — | 1 | 5.01 |
| CHEMBL436424 | — | — | 1 | 4.69 |
| CHEMBL157220 | — | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405761 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL152338 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL153866 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL152256 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL347128 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL152475 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL287727 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3143447 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL406254 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL3143935 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL154209 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL262742 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL152257 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL152838 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL152575 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL436424 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL157220 | — | IC50 | = | 70000.0 | nM | 4.16 |