Assay Detail
Binding
CHEMBL811328
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Inhibitory activity against Tachykinin receptor 3 in guinea pig cortical membranes labeled with [125 I]-[MePhe7]
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Use of a dipeptide chemical library in the development of non-peptide tachykinin NK3 receptor selective antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.10 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45340 | — | — | 1 | 8.40 |
| CHEMBL444832 | — | — | 1 | 8.05 |
| CHEMBL47146 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45340 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL444832 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL47146 | — | IC50 | = | 14.0 | nM | 7.85 |