Assay Detail
Binding
CHEMBL811441
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Inhibitory constant against thermolysin.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus thermoproteolyticus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Definition and display of steric, hydrophobic, and hydrogen-bonding properties of ligand binding sites in proteins using Lee and Richards accessible surface: validation of a high-resolution graphical tool for drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.67 | 10.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44737 | — | — | 1 | 10.17 |
| CHEMBL416089 | — | — | 1 | 8.04 |
| CHEMBL479579 | PHOSPHORAMIDON | — | 1 | 7.55 |
| CHEMBL43735 | — | — | 1 | 7.30 |
| CHEMBL45212 | — | — | 1 | 6.37 |
| CHEMBL46225 | — | — | 1 | 6.12 |
| CHEMBL10247 | THIORPHAN | -1.0 | 1 | 5.75 |
| CHEMBL45412 | — | — | 1 | 5.64 |
| CHEMBL48051 | — | — | 1 | 5.05 |
| CHEMBL47541 | — | — | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44737 | — | Ki | = | 0.068 | nM | 10.17 |
| CHEMBL416089 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL479579 | PHOSPHORAMIDON | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL43735 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL45212 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL46225 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL10247 | THIORPHAN | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL45412 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL48051 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL47541 | — | Ki | = | 21300.0 | nM | 4.67 |