Assay Detail
Binding
CHEMBL811472
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In vitro inhibitory concentration against TEM-1 enzyme
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new beta-lactamase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.50 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | 7.22 |
| CHEMBL267863 | — | — | 1 | 6.22 |
| CHEMBL6281 | — | — | 1 | 6.16 |
| CHEMBL6220 | — | — | 1 | 6.00 |
| CHEMBL403 | SULBACTAM | 4.0 | 1 | 5.85 |
| CHEMBL6292 | — | — | 1 | 5.80 |
| CHEMBL6221 | — | — | 1 | 5.55 |
| CHEMBL6311 | — | — | 1 | 5.19 |
| CHEMBL6261 | — | — | 1 | 5.10 |
| CHEMBL6301 | — | — | 1 | 5.08 |
| CHEMBL6309 | — | — | 1 | 5.07 |
| CHEMBL267627 | — | — | 1 | 4.92 |
| CHEMBL6286 | — | — | 1 | 4.92 |
| CHEMBL263882 | — | — | 1 | 4.82 |
| CHEMBL267626 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404 | TAZOBACTAM | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL267863 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL6281 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL6220 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL403 | SULBACTAM | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL6292 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL6221 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL6311 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL6261 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL6301 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL6309 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL267627 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL6286 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL263882 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL267626 | — | IC50 | = | 24000.0 | nM | 4.62 |