Assay Detail
Binding
CHEMBL811488
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Inhibitory activity against TGF-beta type I receptor
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel and potent transforming growth factor beta type I receptor kinase domain inhibitor: 7-amino 4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.44 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330814 | — | — | 1 | 7.33 |
| CHEMBL332344 | — | — | 1 | 7.32 |
| CHEMBL121554 | — | — | 1 | 7.27 |
| CHEMBL122583 | — | — | 1 | 7.15 |
| CHEMBL119976 | — | — | 1 | 7.11 |
| CHEMBL120587 | — | — | 1 | 7.06 |
| CHEMBL121795 | — | — | 1 | 6.98 |
| CHEMBL119936 | — | — | 1 | 6.96 |
| CHEMBL120211 | — | — | 1 | 6.92 |
| CHEMBL325405 | — | — | 1 | 6.82 |
| CHEMBL121790 | — | — | 1 | 6.76 |
| CHEMBL120718 | — | — | 1 | 6.46 |
| CHEMBL120907 | — | — | 1 | 6.19 |
| CHEMBL333798 | — | — | 1 | 6.06 |
| CHEMBL120245 | — | — | 1 | 5.89 |
| CHEMBL120799 | — | — | 1 | 5.88 |
| CHEMBL122414 | — | — | 1 | 5.58 |
| CHEMBL118339 | — | — | 1 | 5.40 |
| CHEMBL331703 | — | — | 1 | 5.03 |
| CHEMBL122524 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330814 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL332344 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL121554 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL122583 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL119976 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL120587 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL121795 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL119936 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL120211 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL325405 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL121790 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL120718 | — | IC50 | = | 343.0 | nM | 6.46 |
| CHEMBL120907 | — | IC50 | = | 646.0 | nM | 6.19 |
| CHEMBL333798 | — | IC50 | = | 877.0 | nM | 6.06 |
| CHEMBL120245 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL120799 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL122414 | — | IC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL118339 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL331703 | — | IC50 | = | 9290.0 | nM | 5.03 |
| CHEMBL122524 | — | IC50 | = | 19500.0 | nM | 4.71 |