Compound Detail
CHEMBL122524
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Basic Information
| ChEMBL ID | CHEMBL122524 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PWGRLGIJMFMNRG-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
353.4
MW (Da)
3.27
ALogP
5
HBA
0
HBD
64.8
PSA (Ų)
0.72
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.71
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Thyroid hormone receptor beta CHEMBL1947 | IC50 | 4.71 | 4.71 | 19500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Thyroid hormone receptor beta | IC50 | = | 19500.0 | nM | 4.71 | Inhibitory activity against TGF-beta type I receptor | 15177480 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15177480 | 10.1016/j.bmcl.2004.04.065 | Thyroid hormone receptor beta | 1 |
| 15177480 | 10.1016/j.bmcl.2004.04.065 | Unchecked | 1 |
| 15177480 | 10.1016/j.bmcl.2004.04.065 | NIH3T3 | 1 |
| 15177480 | 10.1016/j.bmcl.2004.04.065 | Mitogen-activated protein kinase 14 | 1 |
Data from ChEMBL 36 via Core Engine