Assay Detail
Binding
CHEMBL811694
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Inhibition of thioredoxin reductase
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.69 | 5.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL91078 | — | — | 1 | 5.06 |
| CHEMBL88230 | — | — | 1 | 4.92 |
| CHEMBL89475 | — | — | 1 | 4.87 |
| CHEMBL91371 | — | — | 1 | 4.70 |
| CHEMBL91726 | — | — | 1 | 4.30 |
| CHEMBL313317 | — | — | 1 | 4.30 |
| CHEMBL329895 | — | — | 1 | - |
| CHEMBL312843 | — | — | 1 | - |
| CHEMBL329397 | — | — | 1 | - |
| CHEMBL89858 | — | — | 1 | - |
| CHEMBL88831 | — | — | 1 | - |
| CHEMBL419314 | — | — | 1 | - |
| CHEMBL89586 | — | — | 1 | - |
| CHEMBL440697 | — | — | 1 | - |
| CHEMBL88268 | — | — | 1 | - |
| CHEMBL316338 | — | — | 1 | - |
| CHEMBL86881 | — | — | 1 | - |
| CHEMBL86449 | — | — | 1 | - |
| CHEMBL91727 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL91078 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL88230 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL89475 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL91371 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL91726 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL313317 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL329895 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL312843 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL329397 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL89858 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL88831 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL419314 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL89586 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL440697 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL88268 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL316338 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL86881 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL86449 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL91727 | — | IC50 | > | 50000.0 | nM | - |