Assay Detail
Functional
CHEMBL811699
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration necessary to double the time required for clot formation induced by the addition of 4 NIH u/mL(final concentration) bovine thrombin.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Pyrazoles, 1,2,4-triazoles, and tetrazoles as surrogates for cis-amide bonds in boronate ester thrombin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.49 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2373344 | — | — | 1 | 5.89 |
| CHEMBL2373350 | — | — | 1 | 5.35 |
| CHEMBL2373349 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2373344 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL2373350 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL2373349 | — | Ki | = | 6000.0 | nM | 5.22 |