Assay Detail
Binding
CHEMBL811714
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Half-maximum activation of human Thyroid hormone receptor beta 1 (hTRbeta1)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.39 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1544 | LIOTHYRONINE | 4.0 | 1 | 8.70 |
| CHEMBL107400 | SOBETIROME | 2.0 | 1 | 8.15 |
| CHEMBL109430 | — | — | 1 | 6.42 |
| CHEMBL111953 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1544 | LIOTHYRONINE | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL107400 | SOBETIROME | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL109430 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL111953 | — | EC50 | = | 500.0 | nM | 6.30 |