Compound Detail
CHEMBL107400
SOBETIROME 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL107400 |
| Name | SOBETIROME |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | QNAZTOHXCZPOSA-UHFFFAOYSA-N |
2
Targets
16
Activities
3
Assay Types
7
PK Parameters
20
Publications
4
Known Names
2
Indications
Molecular Properties
328.4
MW (Da)
4.19
ALogP
3
HBA
2
HBD
66.8
PSA (Ų)
0.83
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Adrenoleukodystrophy Adrenoleukodystrophy
Activity Summary
EC50 8 meas. best 8.55
Kd 6 meas. best 10.0
Ki 2 meas. best 9.49
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Thyroid hormone receptor beta CHEMBL1947 | Kd | 10.0 | 9.9 | 0.1 | 3 |
| Thyroid hormone receptor beta CHEMBL1947 | Ki | 9.49 | 9.49 | 0.3 | 1 |
| Thyroid hormone receptor alpha CHEMBL1860 | Kd | 9.18 | 8.84 | 0.7 | 3 |
| Thyroid hormone receptor alpha CHEMBL1860 | Ki | 8.96 | 8.96 | 1.1 | 1 |
| Thyroid hormone receptor beta CHEMBL1947 | EC50 | 8.55 | 8.15 | 2.8 | 4 |
| Thyroid hormone receptor alpha CHEMBL1860 | EC50 | 8.52 | 7.575 | 3.0 | 4 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 681.7 | hr.ng/g | Mus musculus |
| AUC | 10.8 | hr.ng/g | Mus musculus |
| AUC | 2933.0 | hr.ng/g | Mus musculus |
| CL | 8.0 | mL.min-1.kg-1 | Mus musculus |
| F | 92.0 | % | Mus musculus |
| T1/2 | 7.12 | hr | Mus musculus |
| T1/2 | 1.3 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine