Assay Detail
Binding
CHEMBL811899
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Binding affinity of compound was determined against thyroid hormone receptor beta 1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structural determinants of selective thyromimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 9.32 | 10.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1544 | LIOTHYRONINE | 4.0 | 1 | 10.06 |
| CHEMBL107400 | SOBETIROME | 2.0 | 1 | 10.00 |
| CHEMBL419016 | — | — | 1 | 9.44 |
| CHEMBL110335 | — | — | 1 | 8.90 |
| CHEMBL105983 | — | — | 1 | 8.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1544 | LIOTHYRONINE | Kd | = | 0.087 | nM | 10.06 |
| CHEMBL107400 | SOBETIROME | Kd | = | 0.1 | nM | 10.00 |
| CHEMBL419016 | — | Kd | = | 0.36 | nM | 9.44 |
| CHEMBL110335 | — | Kd | = | 1.26 | nM | 8.90 |
| CHEMBL105983 | — | Kd | = | 6.2 | nM | 8.21 |