Assay Detail
Binding
CHEMBL949480
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of a series of liver-selective phosphonic acid thyroid hormone receptor agonists and their prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 8.00 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41036 | — | — | 1 | 9.62 |
| CHEMBL107400 | SOBETIROME | 2.0 | 1 | 9.49 |
| CHEMBL46882 | — | — | 1 | 9.33 |
| CHEMBL1544 | LIOTHYRONINE | 4.0 | 1 | 9.17 |
| CHEMBL512383 | — | — | 1 | 9.08 |
| CHEMBL457528 | — | — | 1 | 9.01 |
| CHEMBL511862 | — | — | 1 | 8.82 |
| CHEMBL457527 | — | — | 1 | 8.60 |
| CHEMBL486359 | — | — | 1 | 8.60 |
| CHEMBL471488 | MB07344 | -1.0 | 1 | 8.53 |
| CHEMBL448595 | — | — | 1 | 8.18 |
| CHEMBL485758 | — | — | 1 | 8.04 |
| CHEMBL485928 | — | — | 1 | 8.01 |
| CHEMBL519721 | — | — | 1 | 7.81 |
| CHEMBL457529 | — | — | 1 | 7.59 |
| CHEMBL459148 | — | — | 1 | 7.58 |
| CHEMBL516330 | — | — | 1 | 7.52 |
| CHEMBL519215 | — | — | 1 | 7.50 |
| CHEMBL505084 | — | — | 1 | 7.44 |
| CHEMBL458784 | — | — | 1 | 7.38 |
| CHEMBL486358 | — | — | 1 | 7.28 |
| CHEMBL447378 | — | — | 1 | 7.06 |
| CHEMBL485927 | — | — | 1 | 7.05 |
| CHEMBL485939 | — | — | 1 | 6.97 |
| CHEMBL486158 | — | — | 1 | 6.89 |
| CHEMBL520857 | — | — | 1 | 6.84 |
| CHEMBL500875 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41036 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL107400 | SOBETIROME | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL46882 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL1544 | LIOTHYRONINE | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL512383 | — | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL457528 | — | Ki | = | 0.97 | nM | 9.01 |
| CHEMBL511862 | — | Ki | = | 1.51 | nM | 8.82 |
| CHEMBL457527 | — | Ki | = | 2.51 | nM | 8.60 |
| CHEMBL486359 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL471488 | MB07344 | Ki | = | 2.95 | nM | 8.53 |
| CHEMBL448595 | — | Ki | = | 6.64 | nM | 8.18 |
| CHEMBL485758 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL485928 | — | Ki | = | 9.72 | nM | 8.01 |
| CHEMBL519721 | — | Ki | = | 15.5 | nM | 7.81 |
| CHEMBL457529 | — | Ki | = | 25.4 | nM | 7.59 |
| CHEMBL459148 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL516330 | — | Ki | = | 30.5 | nM | 7.52 |
| CHEMBL519215 | — | Ki | = | 31.3 | nM | 7.50 |
| CHEMBL505084 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL458784 | — | Ki | = | 42.1 | nM | 7.38 |
| CHEMBL486358 | — | Ki | = | 52.3 | nM | 7.28 |
| CHEMBL447378 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL485927 | — | Ki | = | 89.7 | nM | 7.05 |
| CHEMBL485939 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL486158 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL520857 | — | Ki | = | 146.0 | nM | 6.84 |
| CHEMBL500875 | — | Ki | = | 271.0 | nM | 6.57 |