Assay Detail
Binding
CHEMBL811734
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Inhibitory effect against phosphorylation of [methyl-3H]dThd by Thymidine Kinase 2 (TK-2)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.92 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101135 | — | — | 1 | 5.82 |
| CHEMBL134471 | — | — | 1 | 5.48 |
| CHEMBL341163 | — | — | 1 | 5.44 |
| CHEMBL337264 | — | — | 1 | 5.34 |
| CHEMBL335866 | — | — | 1 | 5.34 |
| CHEMBL134857 | — | — | 1 | 5.01 |
| CHEMBL134449 | — | — | 1 | 4.96 |
| CHEMBL135863 | — | — | 1 | 4.77 |
| CHEMBL135496 | — | — | 1 | 4.72 |
| CHEMBL334803 | — | — | 1 | 4.70 |
| CHEMBL132921 | — | — | 1 | 4.66 |
| CHEMBL422810 | — | — | 1 | 4.60 |
| CHEMBL135079 | — | — | 1 | 4.55 |
| CHEMBL335521 | — | — | 1 | 4.52 |
| CHEMBL2403290 | — | — | 1 | 4.48 |
| CHEMBL435798 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101135 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL134471 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL341163 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL337264 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL335866 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL134857 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL134449 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL135863 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL135496 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL334803 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL132921 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL422810 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL135079 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL335521 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2403290 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL435798 | — | IC50 | = | 40000.0 | nM | 4.40 |