Assay Detail
Binding
CHEMBL811966
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Inhibition of thrombin in human plasma
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Small, low nanomolar, noncovalent thrombin inhibitors lacking a group to fill the 'distal binding pocket'.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 8.05 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296737 | — | — | 1 | 10.40 |
| CHEMBL431524 | — | — | 1 | 10.15 |
| CHEMBL42039 | — | — | 1 | 9.13 |
| CHEMBL19080 | L-375378 | — | 1 | 9.10 |
| CHEMBL42495 | — | — | 1 | 8.30 |
| CHEMBL296041 | — | — | 1 | 8.15 |
| CHEMBL44226 | — | — | 1 | 8.13 |
| CHEMBL45062 | — | — | 1 | 8.07 |
| CHEMBL46638 | — | — | 1 | 7.92 |
| CHEMBL43641 | — | — | 1 | 7.82 |
| CHEMBL43145 | — | — | 1 | 7.75 |
| CHEMBL42091 | — | — | 1 | 7.62 |
| CHEMBL44249 | — | — | 1 | 6.47 |
| CHEMBL44868 | — | — | 1 | 6.05 |
| CHEMBL42496 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296737 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL431524 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL42039 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL19080 | L-375378 | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL42495 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL296041 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL44226 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL45062 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL46638 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL43641 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL43145 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL42091 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL44249 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL44868 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL42496 | — | Ki | = | 2100.0 | nM | 5.68 |