Assay Detail
Binding
CHEMBL811972
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Inhibition constant for binding with thrombin was determined
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The solution conformation of (D)Phe-Pro-containing peptides: implications on the activity of Ac-(D)Phe-Pro-boroArg-OH, a potent thrombin inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.84 | 10.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290376 | — | — | 1 | 10.39 |
| CHEMBL2028992 | — | — | 1 | 9.40 |
| CHEMBL2028996 | — | — | 1 | 8.48 |
| CHEMBL2028995 | — | — | 1 | 8.37 |
| CHEMBL53163 | — | — | 1 | 7.58 |
| CHEMBL2028993 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290376 | — | Ki | = | 0.041 | nM | 10.39 |
| CHEMBL2028992 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL2028996 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL2028995 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL53163 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL2028993 | — | Ki | = | 0.004 | nM | - |