Assay Detail
Binding
CHEMBL811973
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Inhibition of thrombin in human mast cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Dibasic inhibitors of human mast cell tryptase. Part 3: identification of a series of potent and selective inhibitors containing the benzamidine functionality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 4.35 | 4.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43938 | — | — | 1 | 4.68 |
| CHEMBL295450 | — | — | 1 | 4.50 |
| CHEMBL42899 | — | — | 1 | 4.38 |
| CHEMBL297220 | — | — | 1 | 4.38 |
| CHEMBL295007 | — | — | 1 | 4.28 |
| CHEMBL298256 | — | — | 1 | 4.22 |
| CHEMBL38054 | — | — | 1 | 4.03 |
| CHEMBL297408 | — | — | 1 | - |
| CHEMBL40491 | — | — | 1 | - |
| CHEMBL42364 | — | — | 1 | - |
| CHEMBL42898 | — | — | 1 | - |
| CHEMBL42037 | — | — | 1 | - |
| CHEMBL289918 | — | — | 1 | - |
| CHEMBL406192 | — | — | 1 | - |
| CHEMBL296733 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43938 | — | Ki | = | 20800.0 | nM | 4.68 |
| CHEMBL295450 | — | Ki | = | 31900.0 | nM | 4.50 |
| CHEMBL42899 | — | Ki | = | 41200.0 | nM | 4.38 |
| CHEMBL297220 | — | Ki | = | 42200.0 | nM | 4.38 |
| CHEMBL295007 | — | Ki | = | 52900.0 | nM | 4.28 |
| CHEMBL298256 | — | Ki | = | 59500.0 | nM | 4.22 |
| CHEMBL38054 | — | Ki | = | 94400.0 | nM | 4.03 |
| CHEMBL297408 | — | Ki | = | 386000.0 | nM | - |
| CHEMBL40491 | — | Ki | = | 111000.0 | nM | - |
| CHEMBL42364 | — | Ki | = | 561000.0 | nM | - |
| CHEMBL42898 | — | Ki | = | 102000.0 | nM | - |
| CHEMBL42037 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL289918 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL406192 | — | Ki | = | 423000.0 | nM | - |
| CHEMBL296733 | — | Ki | > | 1000000.0 | nM | - |