Assay Detail
Binding
CHEMBL811983
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In vitro inhibition of human thrombin.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Noncovalent thrombin inhibitors incorporating an imidazolylethynyl P1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 7.47 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7962 | — | — | 1 | 9.40 |
| CHEMBL327189 | — | — | 1 | 9.10 |
| CHEMBL94787 | — | — | 1 | 8.59 |
| CHEMBL407631 | — | — | 1 | 8.52 |
| CHEMBL7587 | — | — | 1 | 8.30 |
| CHEMBL96502 | — | — | 1 | 7.92 |
| CHEMBL7197 | — | — | 1 | 7.85 |
| CHEMBL319996 | — | — | 1 | 7.82 |
| CHEMBL327601 | — | — | 1 | 7.62 |
| CHEMBL444548 | — | — | 1 | 7.54 |
| CHEMBL330531 | — | — | 1 | 7.36 |
| CHEMBL317167 | — | — | 1 | 6.68 |
| CHEMBL96484 | — | — | 1 | 6.32 |
| CHEMBL96320 | — | — | 1 | 5.92 |
| CHEMBL329071 | — | — | 1 | 5.27 |
| CHEMBL94759 | — | — | 1 | 5.26 |
| CHEMBL328360 | — | — | 1 | - |
| CHEMBL96298 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7962 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL327189 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL94787 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL407631 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL7587 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL96502 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL7197 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL319996 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL327601 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL444548 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL330531 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL317167 | — | Ki | = | 208.0 | nM | 6.68 |
| CHEMBL96484 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL96320 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL329071 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL94759 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL328360 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL96298 | — | Ki | > | 20000.0 | nM | - |