Assay Detail
Binding
CHEMBL812008
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Steroid 5-alpha-reductase type I from rat ventral prostate (RVP)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Prostate gland |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (CHEMBL3422) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and evaluation of 2'-substituted 4-(4'-carboxy- or 4'-carboxymethylbenzylidene)-N-acylpiperidines: highly potent and in vivo active steroid 5alpha-reductase type 2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.89 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL710 | FINASTERIDE | 4.0 | 1 | 8.00 |
| CHEMBL114594 | — | — | 1 | 6.27 |
| CHEMBL117881 | — | — | 1 | 5.96 |
| CHEMBL117643 | — | — | 1 | 5.80 |
| CHEMBL116621 | — | — | 1 | 5.72 |
| CHEMBL115123 | — | — | 1 | 5.57 |
| CHEMBL115438 | — | — | 1 | 5.50 |
| CHEMBL115298 | — | — | 1 | 5.47 |
| CHEMBL323856 | — | — | 1 | 5.35 |
| CHEMBL114114 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL710 | FINASTERIDE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL114594 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL117881 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL117643 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL116621 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL115123 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL115438 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL115298 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL323856 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL114114 | — | IC50 | = | 5600.0 | nM | 5.25 |