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Assay Detail

CHEMBL812183

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition of human T-cell proliferation
ChEMBL ↗
97
Total Activities
97
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type T-cell
Confidence 1 — Organism
Curated By Expert

Target

T-cell (CHEMBL614309) ↗
Type CELL-LINE

Publication

Potent reversible inhibitors of the protein tyrosine phosphatase CD45.
Urbanek RA, Suchard SJ, Steelman GB, Knappenberger KS, Sygowski LA, Veale CA, Chapdelaine MJ.
J Med Chem (2001) 44 : 1777 -1793
PubMed 11356112 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 97 5.65 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL51314 — — 1 7.00
CHEMBL51447 — — 1 6.70
CHEMBL50973 — — 1 6.70
CHEMBL50627 — — 1 6.70
CHEMBL51880 — — 1 6.70
CHEMBL417727 — — 1 6.70
CHEMBL54165 — — 1 6.70
CHEMBL49236 — — 1 6.70
CHEMBL301793 — — 1 6.52
CHEMBL298582 — — 1 6.52
CHEMBL51931 9,10-PHENANTHRENEQUINONE — 1 6.52
CHEMBL54131 — — 1 6.50
CHEMBL298183 — — 1 6.40
CHEMBL50187 — — 1 6.40
CHEMBL49992 — — 1 6.40
CHEMBL300680 — — 1 6.30
CHEMBL51579 — — 1 6.30
CHEMBL52388 — — 1 6.22
CHEMBL38066 — — 1 6.22
CHEMBL52491 — — 1 6.22
CHEMBL300663 — — 1 6.16
CHEMBL54164 — — 1 6.10
CHEMBL50846 — — 1 6.10
CHEMBL299374 — — 1 6.10
CHEMBL51781 — — 1 6.00
CHEMBL53966 — — 1 6.00
CHEMBL51257 — — 1 5.96
CHEMBL51776 — — 1 5.96
CHEMBL298384 — — 1 5.89
CHEMBL295944 — — 1 5.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL51314 — IC50 = 100.0 nM 7.00
CHEMBL51447 — IC50 = 200.0 nM 6.70
CHEMBL49236 — IC50 = 200.0 nM 6.70
CHEMBL54165 — IC50 = 200.0 nM 6.70
CHEMBL417727 — IC50 = 200.0 nM 6.70
CHEMBL50627 — IC50 = 200.0 nM 6.70
CHEMBL50973 — IC50 = 200.0 nM 6.70
CHEMBL51880 — IC50 = 200.0 nM 6.70
CHEMBL301793 — IC50 = 300.0 nM 6.52
CHEMBL298582 — IC50 = 300.0 nM 6.52
CHEMBL51931 9,10-PHENANTHRENEQUINONE IC50 = 300.0 nM 6.52
CHEMBL54131 — IC50 = 320.0 nM 6.50
CHEMBL298183 — IC50 = 400.0 nM 6.40
CHEMBL50187 — IC50 = 400.0 nM 6.40
CHEMBL49992 — IC50 = 400.0 nM 6.40
CHEMBL300680 — IC50 = 500.0 nM 6.30
CHEMBL51579 — IC50 = 500.0 nM 6.30
CHEMBL52388 — IC50 = 600.0 nM 6.22
CHEMBL38066 — IC50 = 600.0 nM 6.22
CHEMBL52491 — IC50 = 600.0 nM 6.22
CHEMBL300663 — IC50 = 700.0 nM 6.16
CHEMBL54164 — IC50 = 800.0 nM 6.10
CHEMBL50846 — IC50 = 800.0 nM 6.10
CHEMBL299374 — IC50 = 800.0 nM 6.10
CHEMBL53966 — IC50 = 1000.0 nM 6.00
CHEMBL51781 — IC50 = 1000.0 nM 6.00
CHEMBL51257 — IC50 = 1100.0 nM 5.96
CHEMBL51776 — IC50 = 1100.0 nM 5.96
CHEMBL298384 — IC50 = 1300.0 nM 5.89
CHEMBL295944 — IC50 = 1300.0 nM 5.89
CHEMBL300664 — IC50 = 1300.0 nM 5.89
CHEMBL50347 — IC50 = 1300.0 nM 5.89
CHEMBL50149 — IC50 = 1300.0 nM 5.89
CHEMBL51322 — IC50 = 1500.0 nM 5.82
CHEMBL49990 — IC50 = 1500.0 nM 5.82
CHEMBL50161 — IC50 = 1600.0 nM 5.80
CHEMBL433282 — IC50 = 1600.0 nM 5.80
CHEMBL51583 — IC50 = 1700.0 nM 5.77
CHEMBL51948 — IC50 = 1700.0 nM 5.77
CHEMBL51039 — IC50 = 2100.0 nM 5.68
CHEMBL299154 — IC50 = 2200.0 nM 5.66
CHEMBL51317 — IC50 = 2900.0 nM 5.54
CHEMBL2372854 — IC50 = 3000.0 nM 5.52
CHEMBL50878 — IC50 = 3100.0 nM 5.51
CHEMBL2372893 — IC50 = 3300.0 nM 5.48
CHEMBL51637 — IC50 = 3500.0 nM 5.46
CHEMBL300241 — IC50 = 4400.0 nM 5.36
CHEMBL2372886 — IC50 = 5000.0 nM 5.30
CHEMBL2372876 — IC50 = 5000.0 nM 5.30
CHEMBL2372875 — IC50 = 5500.0 nM 5.26