Assay Detail

CHEMBL812184

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Functional

Inhibitory activity against IL-2 induced proliferation in human T-cells

ChEMBL ↗

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Target

T-cell (CHEMBL614309) ↗

Open DB target context

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Primary target T-cell

CHEMBL614309

Anchored from Assay target.

Protein identity T-cell

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	T-cell
Confidence	1 — Organism
Curated By	Intermediate

Target

T-cell (CHEMBL614309) ↗

Type

CELL-LINE

Publication

Mapping the kinase domain of Janus Kinase 3.

Adams C, Aldous DJ, Amendola S, Bamborough P, Bright C, Crowe S, Eastwood P, Fenton G, Foster M, Harrison TK, King S, Lai J, Lawrence C, Letallec JP, McCarthy C, Moorcroft N, Page K, Rao S, Redford J, Sadiq S, Smith K, Souness JE, Thurairatnam S, Vine M, Wyman B.
Bioorg Med Chem Lett (2003) 13 : 3105 -3110
PubMed 12941344 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.70	5.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL320646	—	—	1	5.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL320646	—	IC50	=	2000.0	nM	5.70