Assay Detail
Functional
CHEMBL812229
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against Tachykinin receptor 1
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Use of CoMFA in validating the conformation used in designing 4-(1H-benzimidazole-2-carbonyl)piperidines with H1/NK1 receptor antagonist activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 8.15 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96466 | — | — | 1 | 8.30 |
| CHEMBL95051 | — | — | 1 | 8.28 |
| CHEMBL330462 | — | — | 1 | 8.23 |
| CHEMBL98076 | — | — | 1 | 8.23 |
| CHEMBL327497 | — | — | 1 | 8.21 |
| CHEMBL264007 | — | — | 1 | 8.19 |
| CHEMBL94726 | — | — | 1 | 8.19 |
| CHEMBL329055 | — | — | 1 | 8.18 |
| CHEMBL319535 | — | — | 1 | 8.18 |
| CHEMBL94906 | — | — | 1 | 8.16 |
| CHEMBL94834 | — | — | 1 | 8.16 |
| CHEMBL320002 | — | — | 1 | 8.16 |
| CHEMBL96441 | — | — | 1 | 8.16 |
| CHEMBL273915 | — | — | 1 | 8.15 |
| CHEMBL320003 | — | — | 1 | 8.14 |
| CHEMBL330499 | — | — | 1 | 8.13 |
| CHEMBL330719 | — | — | 1 | 8.13 |
| CHEMBL97357 | — | — | 1 | 8.13 |
| CHEMBL98079 | — | — | 1 | 8.13 |
| CHEMBL93519 | — | — | 1 | 8.13 |
| CHEMBL93556 | — | — | 1 | 8.13 |
| CHEMBL327888 | — | — | 1 | 8.13 |
| CHEMBL411691 | — | — | 1 | 8.13 |
| CHEMBL330172 | — | — | 1 | 8.12 |
| CHEMBL95243 | — | — | 1 | 8.12 |
| CHEMBL95127 | — | — | 1 | 8.12 |
| CHEMBL322194 | — | — | 1 | 8.12 |
| CHEMBL96141 | — | — | 1 | 8.12 |
| CHEMBL94480 | — | — | 1 | 8.12 |
| CHEMBL318369 | — | — | 1 | 8.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96466 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL95051 | — | IC50 | = | 5.28 | nM | 8.28 |
| CHEMBL98076 | — | IC50 | = | 5.86 | nM | 8.23 |
| CHEMBL330462 | — | IC50 | = | 5.91 | nM | 8.23 |
| CHEMBL327497 | — | IC50 | = | 6.21 | nM | 8.21 |
| CHEMBL264007 | — | IC50 | = | 6.52 | nM | 8.19 |
| CHEMBL94726 | — | IC50 | = | 6.43 | nM | 8.19 |
| CHEMBL329055 | — | IC50 | = | 6.54 | nM | 8.18 |
| CHEMBL319535 | — | IC50 | = | 6.54 | nM | 8.18 |
| CHEMBL96441 | — | IC50 | = | 6.98 | nM | 8.16 |
| CHEMBL94834 | — | IC50 | = | 6.93 | nM | 8.16 |
| CHEMBL320002 | — | IC50 | = | 6.84 | nM | 8.16 |
| CHEMBL94906 | — | IC50 | = | 6.93 | nM | 8.16 |
| CHEMBL273915 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL320003 | — | IC50 | = | 7.27 | nM | 8.14 |
| CHEMBL330719 | — | IC50 | = | 7.43 | nM | 8.13 |
| CHEMBL97357 | — | IC50 | = | 7.47 | nM | 8.13 |
| CHEMBL98079 | — | IC50 | = | 7.47 | nM | 8.13 |
| CHEMBL93519 | — | IC50 | = | 7.37 | nM | 8.13 |
| CHEMBL327888 | — | IC50 | = | 7.39 | nM | 8.13 |
| CHEMBL411691 | — | IC50 | = | 7.45 | nM | 8.13 |
| CHEMBL330499 | — | IC50 | = | 7.44 | nM | 8.13 |
| CHEMBL93556 | — | IC50 | = | 7.36 | nM | 8.13 |
| CHEMBL94480 | — | IC50 | = | 7.66 | nM | 8.12 |
| CHEMBL430471 | — | IC50 | = | 7.57 | nM | 8.12 |
| CHEMBL95125 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL328511 | — | IC50 | = | 7.65 | nM | 8.12 |
| CHEMBL96442 | — | IC50 | = | 7.56 | nM | 8.12 |
| CHEMBL318369 | — | IC50 | = | 7.57 | nM | 8.12 |
| CHEMBL96141 | — | IC50 | = | 7.51 | nM | 8.12 |
| CHEMBL322194 | — | IC50 | = | 7.59 | nM | 8.12 |
| CHEMBL95127 | — | IC50 | = | 7.68 | nM | 8.12 |
| CHEMBL95243 | — | IC50 | = | 7.63 | nM | 8.12 |
| CHEMBL330172 | — | IC50 | = | 7.57 | nM | 8.12 |
| CHEMBL94788 | — | IC50 | = | 7.76 | nM | 8.11 |
| CHEMBL97240 | — | IC50 | = | 7.82 | nM | 8.11 |
| CHEMBL95029 | — | IC50 | = | 7.81 | nM | 8.11 |
| CHEMBL95076 | — | IC50 | = | 7.93 | nM | 8.10 |