Assay Detail
Binding
CHEMBL812240
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The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Combined tachykinin receptor antagonist: synthesis and stereochemical structure-activity relationships of novel morpholine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.08 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2115415 | — | — | 1 | 7.68 |
| CHEMBL295615 | — | — | 1 | 7.40 |
| CHEMBL2114963 | — | — | 1 | 6.66 |
| CHEMBL298247 | — | — | 1 | 6.57 |
| CHEMBL295785 | — | — | 1 | - |
| CHEMBL46795 | — | — | 1 | - |
| CHEMBL2115416 | — | — | 1 | - |
| CHEMBL2114965 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2115415 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL295615 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2114963 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL298247 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL295785 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL46795 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2115416 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2114965 | — | IC50 | > | 1000.0 | nM | - |