Assay Detail
Functional
CHEMBL812374
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Immunosuppressive activity was determined as the ability to inhibit T cell proliferation.
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | T-cell |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 9.00 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL412818 | — | — | 1 | 9.74 |
| CHEMBL266443 | — | — | 1 | 9.70 |
| CHEMBL437410 | — | — | 1 | 9.49 |
| CHEMBL440434 | — | — | 1 | 9.47 |
| CHEMBL262995 | — | — | 1 | 9.44 |
| CHEMBL442307 | — | — | 1 | 9.37 |
| CHEMBL265122 | — | — | 1 | 9.35 |
| CHEMBL262406 | — | — | 1 | 9.29 |
| CHEMBL405517 | — | — | 1 | 9.24 |
| CHEMBL8597 | ASCOMYCIN | — | 1 | 9.16 |
| CHEMBL412201 | — | — | 1 | 9.15 |
| CHEMBL428499 | — | — | 1 | 9.10 |
| CHEMBL408603 | — | — | 1 | 9.07 |
| CHEMBL437621 | — | — | 1 | 9.06 |
| CHEMBL276133 | — | — | 1 | 8.96 |
| CHEMBL428447 | — | — | 1 | 8.92 |
| CHEMBL262667 | — | — | 1 | 8.72 |
| CHEMBL385568 | — | — | 1 | 8.68 |
| CHEMBL386482 | — | — | 1 | 8.59 |
| CHEMBL306552 | — | — | 1 | 8.57 |
| CHEMBL405682 | — | — | 1 | 8.39 |
| CHEMBL263345 | — | — | 1 | 8.31 |
| CHEMBL73289 | — | — | 1 | 8.13 |
| CHEMBL268843 | — | — | 1 | 8.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL412818 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL266443 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL437410 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL440434 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL262995 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL442307 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL265122 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL262406 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL405517 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL8597 | ASCOMYCIN | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL412201 | — | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL428499 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL408603 | — | IC50 | = | 0.86 | nM | 9.07 |
| CHEMBL437621 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL276133 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL428447 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL262667 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL385568 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL386482 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL306552 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL405682 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL263345 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL73289 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL268843 | — | IC50 | = | 9.1 | nM | 8.04 |