Assay Detail
Functional
CHEMBL812376
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In vitro evaluation for immunosuppressive activity against proliferation of antigen stimulated murine splenic T cells
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | T-cell |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Alkyl ether analogs of the FK-506 related, immunosuppressive macrolide L-683,590 (ascomycin)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 8.40 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269732 | TACROLIMUS ANHYDROUS | 4.0 | 1 | 9.54 |
| CHEMBL8597 | ASCOMYCIN | — | 1 | 9.16 |
| CHEMBL384325 | — | — | 1 | 9.10 |
| CHEMBL408805 | — | — | 1 | 9.10 |
| CHEMBL406510 | — | — | 1 | 8.72 |
| CHEMBL262667 | — | — | 1 | 8.72 |
| CHEMBL262284 | — | — | 1 | 8.60 |
| CHEMBL409034 | — | — | 1 | 8.57 |
| CHEMBL293155 | — | — | 1 | 8.52 |
| CHEMBL263032 | — | — | 1 | 8.46 |
| CHEMBL265397 | — | — | 1 | 8.42 |
| CHEMBL268338 | — | — | 1 | 8.41 |
| CHEMBL437623 | — | — | 1 | 8.26 |
| CHEMBL412962 | — | — | 1 | 8.26 |
| CHEMBL406329 | — | — | 1 | 8.26 |
| CHEMBL352394 | — | — | 1 | 8.21 |
| CHEMBL171773 | — | — | 1 | 8.16 |
| CHEMBL354218 | — | — | 1 | 8.15 |
| CHEMBL73289 | — | — | 1 | 8.13 |
| CHEMBL405272 | — | — | 1 | 7.95 |
| CHEMBL369581 | — | — | 1 | 7.90 |
| CHEMBL170897 | — | — | 1 | 7.86 |
| CHEMBL410429 | — | — | 1 | 7.85 |
| CHEMBL262492 | — | — | 1 | 7.84 |
| CHEMBL437833 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269732 | TACROLIMUS ANHYDROUS | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL8597 | ASCOMYCIN | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL384325 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL408805 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL406510 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL262667 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL262284 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL409034 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL293155 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL263032 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL265397 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL268338 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL437623 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL412962 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL406329 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL352394 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL171773 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL354218 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL73289 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL405272 | — | IC50 | = | 11.3 | nM | 7.95 |
| CHEMBL369581 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL170897 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL410429 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL262492 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL437833 | — | IC50 | = | 15.8 | nM | 7.80 |