Assay Detail
Binding
CHEMBL812682
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In vitro inhibitory activity against recombinant CD45 protein tyrosine phosphatase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Protein tyrosine phosphatase receptor type C-associated protein (CHEMBL4806) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Aporphine alkaloids, CD45 protein tyrosine phosphatase inhibitors, from Rollinia ulei
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.70 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36496 | NORNUCIFERINE | — | 1 | 5.28 |
| CHEMBL401798 | ANONAINE | — | 1 | 4.77 |
| CHEMBL228082 | GLAUCINE | — | 1 | 4.06 |
| CHEMBL37736 | LIRIODENINE | — | 1 | - |
| CHEMBL36654 | ROEMERINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36496 | NORNUCIFERINE | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL401798 | ANONAINE | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL228082 | GLAUCINE | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL37736 | LIRIODENINE | IC50 | = | 182000.0 | nM | - |
| CHEMBL36654 | ROEMERINE | IC50 | = | 107000.0 | nM | - |