Compound Detail
CHEMBL36496
NORNUCIFERINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL36496 |
| Name | NORNUCIFERINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QQKAHDMMPBQDAC-UHFFFAOYSA-N |
4
Targets
5
Activities
2
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
281.4
MW (Da)
3.11
ALogP
3
HBA
1
HBD
30.5
PSA (Ų)
0.92
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.28
EC50 1 meas. best 6.51
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2C CHEMBL225 | EC50 | 6.51 | 6.51 | 308.0 | 1 |
| Protein tyrosine phosphatase receptor type C-associated protein CHEMBL4806 | IC50 | 5.28 | 5.28 | 5300.0 | 1 |
| EL4 CHEMBL614293 | IC50 | 4.58 | 4.58 | 26240.0 | 1 |
| D(1A) dopamine receptor CHEMBL2056 | IC50 | 4.42 | 4.42 | 38470.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2C | EC50 | = | 308.0 | nM | 6.51 | Partial agonist activity at human 5-HT2C stably transfected in HEK293T cells mea... | 37172474 |
| Protein tyrosine phosphatase receptor type C-associated protein | IC50 | = | 5300.0 | nM | 5.28 | In vitro inhibitory activity against recombinant CD45 protein tyrosine phosphata... | - |
| EL4 | IC50 | = | 26240.0 | nM | 4.58 | Cytotoxicity against mouse EL4 cells assessed as inhibition of cell proliferatio... | 37154394 |
| D(1A) dopamine receptor | IC50 | = | 38470.0 | nM | 4.42 | Antagonist activity at D1R (unknown origin) transfected in HEK293 cells by FLIPR... | 37172474 |
| D(1A) dopamine receptor | IC50 | = | 38470.0 | nM | 4.42 | Agonist activity at D1 receptor (unknown origin) transfected in HEK293 cells by ... | 39038276 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37172474 | 10.1016/j.ejmech.2023.115414 | 5-hydroxytryptamine receptor 2C | 2 |
| - | 10.1016/0960-894X(95)00250-W | Protein tyrosine phosphatase receptor type C-associated protein | 1 |
| 20476748 | 10.1021/np100013r | NON-PROTEIN TARGET | 1 |
| 28499733 | 10.1016/j.bmcl.2017.04.072 | RAW264.7 | 1 |
| 37154394 | 10.1021/acs.jmedchem.3c00287 | EL4 | 1 |
| 37154394 | 10.1021/acs.jmedchem.3c00287 | Aryl hydrocarbon receptor | 1 |
| 37172474 | 10.1016/j.ejmech.2023.115414 | D(1A) dopamine receptor | 1 |
| 39038276 | 10.1021/acs.jmedchem.4c00537 | D(1A) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine