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Assay Detail

CHEMBL812829

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Binding
Binding affinity to human thrombin
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Prothrombin (CHEMBL204)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibitors of serine proteases as potential therapeutic agents: the road from thrombin to tryptase to cathepsin G.
Maryanoff BE.
J Med Chem (2004) 47 : 769 -787
PubMed 14761180 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 19 7.93 10.74

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL353760 1 10.74
CHEMBL270437 1 9.70
CHEMBL353137 1 8.82
CHEMBL403929 1 8.70
CHEMBL322205 1 8.68
CHEMBL352188 1 8.51
CHEMBL102121 1 8.47
CHEMBL434870 1 8.39
CHEMBL105584 1 8.21
CHEMBL256381 1 8.09
CHEMBL101855 1 8.02
CHEMBL165326 1 7.82
CHEMBL163828 1 7.62
CHEMBL404728 1 7.07
CHEMBL272931 1 6.70
CHEMBL2371465 1 6.58
CHEMBL256591 1 5.62
CHEMBL164138 1 4.91
CHEMBL403768 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL353760 Ki = 0.018 nM 10.74
CHEMBL270437 Ki = 0.2 nM 9.70
CHEMBL353137 Ki = 1.5 nM 8.82
CHEMBL403929 Ki = 2.0 nM 8.70
CHEMBL322205 Ki = 2.1 nM 8.68
CHEMBL352188 Ki = 3.1 nM 8.51
CHEMBL102121 Ki = 3.4 nM 8.47
CHEMBL434870 Ki = 4.1 nM 8.39
CHEMBL105584 Ki = 6.2 nM 8.21
CHEMBL256381 Ki = 8.1 nM 8.09
CHEMBL101855 Ki = 9.6 nM 8.02
CHEMBL165326 Ki = 15.0 nM 7.82
CHEMBL163828 Ki = 24.0 nM 7.62
CHEMBL404728 Ki = 85.0 nM 7.07
CHEMBL272931 Ki = 200.0 nM 6.70
CHEMBL2371465 Ki = 260.0 nM 6.58
CHEMBL256591 Ki = 2400.0 nM 5.62
CHEMBL164138 Ki = 12300.0 nM 4.91
CHEMBL403768 Ki = 0.00065 nM -