Assay Detail
Binding
CHEMBL812830
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards human thrombin
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 5.84 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL152854 | — | — | 1 | 6.52 |
| CHEMBL157417 | — | — | 1 | 6.52 |
| CHEMBL160489 | — | — | 1 | 6.52 |
| CHEMBL346825 | — | — | 1 | 6.22 |
| CHEMBL349323 | — | — | 1 | 6.10 |
| CHEMBL152274 | — | — | 1 | 6.05 |
| CHEMBL356016 | — | — | 1 | 6.05 |
| CHEMBL156924 | — | — | 1 | 5.90 |
| CHEMBL153611 | — | — | 1 | 5.70 |
| CHEMBL347606 | — | — | 1 | 5.58 |
| CHEMBL158219 | — | — | 1 | 5.50 |
| CHEMBL157299 | — | — | 1 | 5.48 |
| CHEMBL160958 | — | — | 1 | 5.44 |
| CHEMBL156505 | — | — | 1 | 5.22 |
| CHEMBL351755 | — | — | 1 | 4.81 |
| CHEMBL159204 | — | — | 1 | - |
| CHEMBL160515 | — | — | 1 | - |
| CHEMBL160575 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL152854 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL157417 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL160489 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL346825 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL349323 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL152274 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL356016 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL156924 | — | Ki | = | 1250.0 | nM | 5.90 |
| CHEMBL153611 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL347606 | — | Ki | = | 2640.0 | nM | 5.58 |
| CHEMBL158219 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL157299 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL160958 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL156505 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL351755 | — | Ki | = | 15400.0 | nM | 4.81 |
| CHEMBL159204 | — | Ki | > | 21000.0 | nM | - |
| CHEMBL160515 | — | Ki | > | 6300.0 | nM | - |
| CHEMBL160575 | — | Ki | > | 6300.0 | nM | - |