Assay Detail
Binding
CHEMBL812832
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards thrombin was determined
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Bound structures of novel P3-P1' beta-strand mimetic inhibitors of thrombin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.33 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284549 | — | — | 1 | 10.15 |
| CHEMBL283717 | — | — | 1 | 9.19 |
| CHEMBL32182 | — | — | 1 | 8.62 |
| CHEMBL265317 | — | — | 1 | 8.00 |
| CHEMBL432470 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284549 | — | Ki | = | 0.071 | nM | 10.15 |
| CHEMBL283717 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL32182 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL265317 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL432470 | — | Ki | = | 2000.0 | nM | 5.70 |