Assay Detail
Binding
CHEMBL812833
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Binding affinity towards thrombin was tested.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Rational design of boropeptide thrombin inhibitors: beta, beta-dialkyl-phenethylglycine P2 analogs of DuP 714 with greater selectivity over complement factor I and an improved safety profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 9.39 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL607008 | — | — | 1 | 10.40 |
| CHEMBL102385 | — | — | 1 | 10.22 |
| CHEMBL105137 | — | — | 1 | 10.22 |
| CHEMBL102916 | — | — | 1 | 9.55 |
| CHEMBL320213 | — | — | 1 | 9.52 |
| CHEMBL105212 | — | — | 1 | 9.44 |
| CHEMBL102779 | — | — | 1 | 9.43 |
| CHEMBL319050 | — | — | 1 | 9.39 |
| CHEMBL419734 | — | — | 1 | 9.38 |
| CHEMBL320019 | — | — | 1 | 9.37 |
| CHEMBL103078 | — | — | 1 | 9.28 |
| CHEMBL103077 | — | — | 1 | 9.24 |
| CHEMBL104331 | — | — | 1 | 9.08 |
| CHEMBL105393 | — | — | 1 | 9.05 |
| CHEMBL317639 | — | — | 1 | 8.92 |
| CHEMBL431056 | — | — | 1 | 8.62 |
| CHEMBL102930 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL607008 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL102385 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL105137 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL102916 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL320213 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL105212 | — | Ki | = | 0.36 | nM | 9.44 |
| CHEMBL102779 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL319050 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL419734 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL320019 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL103078 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL103077 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL104331 | — | Ki | = | 0.83 | nM | 9.08 |
| CHEMBL105393 | — | Ki | = | 0.89 | nM | 9.05 |
| CHEMBL317639 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL431056 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL102930 | — | Ki | = | 3.0 | nM | 8.52 |