Assay Detail
Binding
CHEMBL812836
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Binding affinity was evaluated on serine protease thrombin.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.60 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441468 | — | — | 1 | 9.51 |
| CHEMBL327115 | — | — | 1 | 9.35 |
| CHEMBL108717 | — | — | 1 | 9.30 |
| CHEMBL108202 | — | — | 1 | 9.21 |
| CHEMBL42039 | — | — | 1 | 9.13 |
| CHEMBL320080 | — | — | 1 | 8.60 |
| CHEMBL108183 | — | — | 1 | 8.52 |
| CHEMBL42495 | — | — | 1 | 8.30 |
| CHEMBL322321 | — | — | 1 | 7.75 |
| CHEMBL108771 | — | — | 1 | 7.70 |
| CHEMBL111051 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441468 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL327115 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL108717 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL108202 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL42039 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL320080 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL108183 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL42495 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL322321 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL108771 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL111051 | — | Ki | = | 60.0 | nM | 7.22 |