Assay Detail
Binding
CHEMBL812837
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In vitro binding affinity by measuring the inhibition of human thrombin
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of potent and highly selective thrombin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 7.57 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325166 | NAPSAGATRAN ANHYDROUS | 2.0 | 1 | 9.57 |
| CHEMBL341260 | — | — | 1 | 9.17 |
| CHEMBL338669 | — | — | 1 | 9.15 |
| CHEMBL339094 | — | — | 1 | 9.07 |
| CHEMBL409333 | — | — | 1 | 8.51 |
| CHEMBL51173 | — | — | 1 | 8.40 |
| CHEMBL539557 | — | — | 1 | 8.32 |
| CHEMBL126238 | — | — | 1 | 8.17 |
| CHEMBL559194 | — | — | 1 | 8.05 |
| CHEMBL555314 | — | — | 1 | 8.00 |
| CHEMBL543893 | — | — | 1 | 7.89 |
| CHEMBL544356 | — | — | 1 | 7.75 |
| CHEMBL558215 | — | — | 1 | 7.72 |
| CHEMBL1166 | ARGATROBAN | 4.0 | 1 | 7.70 |
| CHEMBL544130 | — | — | 1 | 7.62 |
| CHEMBL544830 | — | — | 1 | 7.50 |
| CHEMBL558610 | — | — | 1 | 7.42 |
| CHEMBL539047 | — | — | 1 | 7.33 |
| CHEMBL552997 | — | — | 1 | 7.20 |
| CHEMBL539559 | — | — | 1 | 7.16 |
| CHEMBL543419 | — | — | 1 | 7.07 |
| CHEMBL543183 | — | — | 1 | 7.03 |
| CHEMBL128980 | — | — | 1 | 7.00 |
| CHEMBL553963 | — | — | 1 | 6.96 |
| CHEMBL540073 | — | — | 1 | 6.89 |
| CHEMBL216318 | — | — | 1 | 6.82 |
| CHEMBL20936 | BENZAMIDINE | — | 1 | 6.52 |
| CHEMBL539815 | — | — | 1 | 6.48 |
| CHEMBL544131 | — | — | 1 | 6.32 |
| CHEMBL542951 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325166 | NAPSAGATRAN ANHYDROUS | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL341260 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL338669 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL339094 | — | Ki | = | 0.86 | nM | 9.07 |
| CHEMBL409333 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL51173 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL539557 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL126238 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL559194 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL555314 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL543893 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL544356 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL558215 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL1166 | ARGATROBAN | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL544130 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL544830 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL558610 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL539047 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL552997 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL539559 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL543419 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL543183 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL128980 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL553963 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL540073 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL216318 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL20936 | BENZAMIDINE | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL539815 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL544131 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL542951 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL340184 | — | Ki | = | 1400.0 | nM | 5.85 |