Assay Detail
Binding
CHEMBL812838
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Binding affinity towards thrombin was evaluated
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.38 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL353431 | — | — | 1 | 9.48 |
| CHEMBL287614 | — | — | 1 | 9.30 |
| CHEMBL11157 | L-374087 | — | 1 | 9.30 |
| CHEMBL349430 | — | — | 1 | 8.64 |
| CHEMBL355441 | — | — | 1 | 7.96 |
| CHEMBL354555 | — | — | 1 | 7.92 |
| CHEMBL96486 | — | — | 1 | 7.92 |
| CHEMBL48929 | — | — | 1 | 7.58 |
| CHEMBL424545 | — | — | 1 | 7.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL353431 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL287614 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL11157 | L-374087 | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL349430 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL355441 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL354555 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL96486 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL48929 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL424545 | — | Ki | = | 47.0 | nM | 7.33 |