Assay Detail
Binding
CHEMBL812840
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Binding affinity was determined against human thrombin
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Estimation of binding affinities for selective thrombin inhibitors via Monte Carlo simulations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.67 | 10.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9582 | — | — | 1 | 10.35 |
| CHEMBL267676 | — | — | 1 | 10.00 |
| CHEMBL9463 | — | — | 1 | 9.92 |
| CHEMBL9664 | — | — | 1 | 9.52 |
| CHEMBL269206 | — | — | 1 | 9.42 |
| CHEMBL1159708 | — | — | 1 | 8.48 |
| CHEMBL9496 | — | — | 1 | 8.42 |
| CHEMBL9507 | — | — | 1 | 8.10 |
| CHEMBL9461 | — | — | 1 | 7.96 |
| CHEMBL273645 | — | — | 1 | 7.74 |
| CHEMBL9293 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9582 | — | Ki | = | 0.045 | nM | 10.35 |
| CHEMBL267676 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL9463 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL9664 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL269206 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL1159708 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL9496 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL9507 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL9461 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL273645 | — | Ki | = | 18.4 | nM | 7.74 |
| CHEMBL9293 | — | Ki | = | 3300.0 | nM | 5.48 |