Assay Detail
Binding
CHEMBL812848
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Inhibitory activity against thromboxane A2 synthetase
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.30 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267473 | DAZOXIBEN | 2.0 | 1 | 8.52 |
| CHEMBL284356 | — | — | 1 | 7.82 |
| CHEMBL33632 | — | — | 1 | 7.82 |
| CHEMBL33731 | — | — | 1 | 7.57 |
| CHEMBL30766 | — | — | 1 | 7.50 |
| CHEMBL30395 | — | — | 1 | 7.25 |
| CHEMBL34041 | — | — | 1 | 7.02 |
| CHEMBL33874 | — | — | 1 | 6.75 |
| CHEMBL33407 | — | — | 1 | 6.28 |
| CHEMBL30861 | — | — | 1 | 6.21 |
| CHEMBL418043 | — | — | 1 | 6.20 |
| CHEMBL284827 | — | — | 1 | 6.18 |
| CHEMBL33151 | — | — | 1 | 6.08 |
| CHEMBL286308 | — | — | 1 | 6.07 |
| CHEMBL423117 | — | — | 1 | 6.07 |
| CHEMBL286092 | — | — | 1 | 5.96 |
| CHEMBL416402 | — | — | 1 | 5.75 |
| CHEMBL33748 | — | — | 1 | 5.70 |
| CHEMBL34574 | — | — | 1 | 5.54 |
| CHEMBL30604 | — | — | 1 | 5.52 |
| CHEMBL281207 | — | — | 1 | 5.46 |
| CHEMBL33690 | — | — | 1 | 5.40 |
| CHEMBL33747 | — | — | 1 | 5.36 |
| CHEMBL33065 | — | — | 1 | 4.89 |
| CHEMBL33210 | — | — | 1 | 4.66 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
| CHEMBL33689 | — | — | 1 | - |
| CHEMBL33514 | — | — | 1 | - |
| CHEMBL540 | IMIDAZOLE | — | 1 | - |
| CHEMBL284963 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267473 | DAZOXIBEN | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL284356 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL33632 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL33731 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL30766 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL30395 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL34041 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL33874 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL33407 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL30861 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL418043 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL284827 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL33151 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL286308 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL423117 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL286092 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL416402 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL33748 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL34574 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL30604 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL281207 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL33690 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL33747 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL33065 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL33210 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL6 | INDOMETHACIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL33689 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL33514 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL540 | IMIDAZOLE | IC50 | = | 670000.0 | nM | - |
| CHEMBL284963 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL34511 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL414614 | — | IC50 | > | 50000.0 | nM | - |