Assay Detail
Binding
CHEMBL812969
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In vitro inhibition of [6,7-3H]E1S binding to steroid sulfatase in JEG-3 human placental carcinoma cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
First dual aromatase-steroid sulfatase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.89 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322322 | — | — | 1 | 7.70 |
| CHEMBL108483 | — | — | 1 | 7.41 |
| CHEMBL108646 | — | — | 1 | 7.40 |
| CHEMBL430879 | — | — | 1 | 6.64 |
| CHEMBL325346 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322322 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL108483 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL108646 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL430879 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL325346 | — | IC50 | = | 5133.0 | nM | 5.29 |