Assay Detail
Functional
CHEMBL812994
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Inhibitory activity to inhibit Inophore-induced arachidonic acid metabolism (inhibition of TXB2 formation) in rat
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
3,4-Dihydro-2H-1-benzopyran-2-carboxylic acids and related compounds as leukotriene antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.11 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.00 |
| CHEMBL267473 | DAZOXIBEN | 2.0 | 1 | 6.52 |
| CHEMBL416657 | — | — | 1 | 5.70 |
| CHEMBL22016 | ABLUKAST | 2.0 | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL267473 | DAZOXIBEN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL416657 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL22016 | ABLUKAST | IC50 | = | 6000.0 | nM | 5.22 |