Assay Detail
Functional
CHEMBL813190
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Cytotoxicity against U373 astrocytoma cells.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-373MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.27 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140363 | — | — | 1 | 7.55 |
| CHEMBL140681 | — | — | 1 | 7.14 |
| CHEMBL140220 | — | — | 1 | 7.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140363 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL140681 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL140220 | — | IC50 | = | 74.0 | nM | 7.13 |