Assay Detail
Binding
CHEMBL813222
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Topoisomerase I by cleavage complex formation in intact human HL-60 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HL-60 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.21 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52057 | — | — | 1 | 7.42 |
| CHEMBL90761 | — | — | 1 | 7.16 |
| CHEMBL315269 | RS-9-Aminocamptothecin | — | 1 | 6.08 |
| CHEMBL276820 | — | — | 1 | 5.80 |
| CHEMBL545250 | — | — | 1 | 5.60 |
| CHEMBL539032 | — | — | 1 | 5.17 |
| CHEMBL558618 | — | — | 1 | - |
| CHEMBL540569 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52057 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL90761 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL315269 | RS-9-Aminocamptothecin | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL276820 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL545250 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL539032 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL558618 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL540569 | — | IC50 | > | 30000.0 | nM | - |